Mechanism of the promotion of GEFS+ by the STAT3-mediated expression of interleukin-6.

ABSTRACT:

Background

Genetic epilepsy with febrile seizures plus (GEFS+) is generally considered an ion channelopathy. To date, there have been few studies on inflammation associated with various types of epilepsy, and it remains unclear whether the inflammatory mechanism plays a key role in epilepsy.

Methods

In order to explore the role of the regulatory mechanism of immune factor expression in the pathogenesis of GEFS+, the present study detected the expression level of relevant immune factors such as interleukin-6 (IL-6) in peripheral blood of GEFS+ mice.

Results

The cluster of differentiation 4⁺/cluster of differentiation 8⁺ (CD4⁺/CD8⁺) ratio in the GEFS+ mice was decreased, while the signal transducer and activator of transcripti

SUBMITTER: Ling Y 

PROVIDER: S-EPMC9561518 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature