Serum lipid traits and the risk of dementia: A cohort study of 254,575 women and 214,891 men in the UK Biobank.

ABSTRACT:

Background

Serum lipid traits are associated with cardiovascular disease, but uncertainty remains regarding their associations with dementia.

Methods

From 2006 to 2010, 254,575 women and 214,891 men were included from the UK Biobank. Cox regression estimated overall and sex-specific hazard ratios (HRs) for apolipoprotein A (ApoA), apolipoprotein B (ApoB), HDL, LDL, total cholesterol, triglycerides, lipoprotein A, and various lipid ratios, by quarters and standard deviation (SD) higher, associated with all-cause dementia, Alzheimer's disease (AD) and vascular dementia (VaD). Subgroup analyses by age and social deprivation were conducted.

Findings

Over 11·8 years (median), 3734 all-cause dementia (1,716 women), 1231 AD and 929 VaD were recorded. Compared to respective l

SUBMITTER: Gong J 

PROVIDER: S-EPMC9561731 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature