Vitamin D and Weight Change: A Mendelian Randomization, Prospective Study.

ABSTRACT: The association between 25-hydroxyvitamin D and 5-, 10-, or 15-year weight change were assessed in a population-based, prospective study conducted in Lausanne, Switzerland. Data from the first (2009-2012, N = 3527, 51.3% women), second (2014-2017, N = 3237, 53.8% women), and third (2018-2021, N = 2567, 54.2% women) follow-ups were used. A weighted genetic risk score (GRS) of 115 SNPs associated with vitamin D levels was constructed. At baseline, the GRS correlated positively with 25-hydroxyvitamin D levels based on a Spearman rank correlation and 95% confidence interval: 0.198 (0.166; 0.231), p < 0.001; and with body mass index: 0.036 (0.004; 0.068), p = 0.028. No association was found between quartiles of GRS and weight changes at 5, 10, or 15 years: multivariate-adjusted

SUBMITTER: Patriota P 

PROVIDER: S-EPMC9569579 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature