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5,5,5-Trichloropent-3-en-one as a Precursor of 1,3-Bi-centered Electrophile in Reactions with Arenes in Bronsted Superacid CF₃SO₃H. Synthesis of 3-Methyl-1-trichloromethylindenes.

ABSTRACT: Reactions of 5,5,5-trichloropent-3-en-2-one Cl₃CCH=CHC(=O)Me with arenes in Brønsted superacid CF₃SO₃H at room temperature for 2 h-5 days afford 3-methyl-1-trichloromethylindenes, a novel class of indene derivatives. The key reactive intermediate, O-protonated form of starting compound Cl₃CCH=CHC(=OH⁺)Me, has been studied experimentally by NMR in CF₃SO₃H and theoretically by DFT calculations. The reaction proceeds through initial hydroarylation of the carbon-carbon double bond of starting CCl₃-enone, followed by cyclization onto the O-protonated carbonyl group, leading to target indenes. In general, 5,5,5-trichloropent-3-en-2-one in CF₃SO₃H acts as a 1,3-bi-centered electrophile.

SUBMITTER: Shershnev IA

PROVIDER: S-EPMC9573653 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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5,5,5-Trichloropent-3-en-one as a Precursor of 1,3-Bi-centered Electrophile in Reactions with Arenes in Brønsted Superacid CF3SO3H. Synthesis of 3-Methyl-1-trichloromethylindenes.

Shershnev Ivan A IA Boyarskaya Irina A IA Vasilyev Aleksander V AV

Molecules (Basel, Switzerland) 20221007 19

Reactions of 5,5,5-trichloropent-3-en-2-one Cl3CCH=CHC(=O)Me with arenes in Brønsted superacid CF3SO3H at room temperature for 2 h-5 days afford 3-methyl-1-trichloromethylindenes, a novel class of indene derivatives. The key reactive intermediate, O-protonated form of starting compound Cl3CCH=CHC(=OH+)Me, has been studied experimentally by NMR in CF3SO3H and theoretically by DFT calculations. The reaction proceed ...[more]

PMID: 36235211

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