Polymorphisms in paired box 1 gene were associated with susceptibility of adolescent idiopathic scoliosis: A case-control study.

ABSTRACT:

Background

Association of genetic polymorphisms in paired box 1 (PAX-1) gene can influence the development of adolescent idiopathic scoliosis (AIS). PAX-1 is mainly expressed in the region of the vertebral bodies and intervertebral discs, being important for the proper formation of spinal structures.

Objectives

The objective of this study was to evaluate the association of polymorphisms in PAX-1 gene with the susceptibility of AIS.

Settings and design

This was an analytical observational case-control study.

Materials and methods

Samples of 59 AIS indicated for surgical treatment, and 119 controls, without spinal disease were genotyped for PAX-1 rs6137473 and rs169311 polymorphisms.

Statistical analysis

The association of the polymorp

SUBMITTER: Pedrosa AE 

PROVIDER: S-EPMC9574104 | biostudies-literature | 2022 Jul-Sep

REPOSITORIES: biostudies-literature