Dataset Information

Minocycline treatment in clinically isolated syndrome and serum NfL, GFAP, and metalloproteinase levels.

ABSTRACT:

Background

In the trial of Minocycline in Clinically Isolated Syndrome (MinoCIS), minocycline significantly reduced the risk of conversion to clinically definite multiple sclerosis (CDMS). Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are emerging biomarkers in MS, and minocycline modulates matrix metalloproteinases (MMPs).

Objective

To assess the value of blood NfL and GFAP as a biomarker of baseline and future disease activity and its utility to monitor treatment response in minocycline-treated patients with clinically isolated syndrome (CIS).

Methods

We measured NfL, GFAP, and MMPs in blood samples from 96 patients with CIS from the MinoCIS study and compared biomarkers with clinical and radiologic characteristics and outcome.

Results

At baseline, NfL levels correlated with T₂ lesion load and number of gadolinium-enhancing lesions. Baseline NfL levels predicted conversion into CDMS at month 6. GFAP levels at baseline were correlated with T₂ lesion volume. Minocycline treatment significantly increased NfL levels at 3 months but not at 6 months, and decreased GFAP levels at month 6. Minocycline decreased MMP-7 concentrations at month 1.

Discussion

Blood NfL levels are associated with measures of disease activity in CIS and have prognostic value. Minocycline increased NfL levels at month 3, but reduced GFAP and MMP-7 levels.

SUBMITTER: Camara-Lemarroy C

PROVIDER: S-EPMC9574233 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Minocycline treatment in clinically isolated syndrome and serum NfL, GFAP, and metalloproteinase levels.

Camara-Lemarroy Carlos C Metz Luanne L Kuhle Jens J Leppert David D Willemse Eline E Li David Kb DK Traboulsee Anthony A Greenfield Jamie J Cerchiaro Graziela G Silva Claudia C Yong V Wee VW

Multiple sclerosis (Houndmills, Basingstoke, England) 20220718 13

<h4>Background</h4>In the trial of Minocycline in Clinically Isolated Syndrome (MinoCIS), minocycline significantly reduced the risk of conversion to clinically definite multiple sclerosis (CDMS). Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are emerging biomarkers in MS, and minocycline modulates matrix metalloproteinases (MMPs).<h4>Objective</h4>To assess the value of blood NfL and GFAP as a biomarker of baseline and future disease activity and its utility to moni ...[more]

PMID: 35848622

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Dataset Information

Minocycline treatment in clinically isolated syndrome and serum NfL, GFAP, and metalloproteinase levels.

Background

Objective

Methods

Results

Discussion

Publications

Minocycline treatment in clinically isolated syndrome and serum NfL, GFAP, and metalloproteinase levels.

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