Role of ductular reaction and ductular-canalicular junctions in identifying severe primary biliary cholangitis.

ABSTRACT:

Background & aims

Primary biliary cholangitis (PBC) is a chronic cholangiopathy characterised by immuno-mediated injury of interlobular bile ducts leading to intrahepatic cholestasis and progressive liver fibrosis. PBC histology is characterised by portal inflammation, progressive fibrosis, ductopenia, and the appearance of the so-called ductular reaction. The aim of the present study was to investigate the pathogenetic relevance of ductular reaction in PBC.

Methods

Liver biopsies were collected from naïve people with PBC (N = 87). Clinical-serological parameters were obtained at diagnosis and after 1 year of ursodeoxycholic acid (UDCA) treatment. Histological staging was performed on all slides according to multiple scoring systems and criteria for PBC. Liver samples were o

SUBMITTER: Overi D 

PROVIDER: S-EPMC9576897 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature