Association of Vitamin B12 deficiency with long-term PPIs use: A cohort study.

ABSTRACT:

Background

Proton Pump inhibitors are widely used among the majority of the world's population as acid-suppressing medications. Proton Pump Inhibitors have been reported to cause intestinal damage and adverse gut microbiota changes affecting several mechanisms, including malabsorption, etc.

Aim

In order to gain a deeper understanding, we conducted a cohort analysis to assess the prevalence & association of Vitamin B12 deficiency in patients on long-term use of PPIs.

Methods

This single-center cohort study was conducted at the Department of Internal Medicine, KRL hospital in Islamabad, Pakistan from May 2021 to May 2022. Rao soft calculator with a 95% confidence interval and 5% error margin was used to find the estimated sample size. Vitamin B₁₂ levels were

SUBMITTER: Mumtaz H 

PROVIDER: S-EPMC9577826 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature