Highly variable biodistribution of ⁶⁸Ga labeled somatostatin analogues ⁶⁸Ga-DOTA-NOC and ⁶⁸Ga-DOTA-TATE in neuroendocrine tumors: clinical implications for somatostatin receptor directed PET/CT.

ABSTRACT:

Background

Somatostatin receptor (SSTR)-targeted positron emission tomography/computed tomography (PET/CT) imaging has risen to the forefront for neuroendocrine tumor (NET) detection and management, yet the variability of significant uptake variability (SUV) as a semiquantitative measure of disease detection and tumor response to treatment has not been fully explored.

Methods

We assess the reproducibility and interscan variability of SUV metrics of normal tissue and NET in serial ⁶⁸Ga-DOTA-NOC and ⁶⁸Ga-DOTA-TATE PET imaging to clinically monitor disease state. Eighty-one patients were enrolled in this retrospective study.

Results

Both primary and metastatic hepatic lesions demonstrated SUV (SUV_mean 16.5±8.0). The median SUV_mean

SUBMITTER: Cheng M 

PROVIDER: S-EPMC9577978 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature