A differential therapeutic consideration for use of corticosteroids according to established COVID-19 clinical phenotypes in critically ill patients.

ABSTRACT:

Objective

To determine if the use of corticosteroids was associated with Intensive Care Unit (ICU) mortality among whole population and pre-specified clinical phenotypes.

Design

A secondary analysis derived from multicenter, observational study.

Setting

Critical Care Units.

Patients

Adult critically ill patients with confirmed COVID-19 disease admitted to 63 ICUs in Spain.

Interventions

Corticosteroids vs. no corticosteroids.

Main variables of interest

Three phenotypes were derived by non-supervised clustering analysis from whole population and classified as (A: severe, B: critical and C: life-threatening). We performed a multivariate analysis after propensity optimal full matching (PS) for whole population and weighted Cox regression (HR) and Fin

SUBMITTER: Moreno G 

PROVIDER: S-EPMC9579897 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature