Construction and analysis of sample-specific driver modules for breast cancer.

ABSTRACT:

Background

It is important to understand the functional impact of somatic mutation and methylation aberration at an individual level to implement precision medicine. Recent studies have demonstrated that the perturbation of gene interaction networks can provide a fundamental link between genotype (or epigenotype) and phenotype. However, it is unclear how individual mutations affect the function of biological networks, especially for individual methylation aberration. To solve this, we provided a sample-specific driver module construction method using the 2-order network theory and hub-gene theory to identify individual perturbation networks driven by mutations or methylation aberrations.

Results

Our method integrated multi-omics of breast cancer, including genomics, transcri

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9583575 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature