Stimuli-responsive vesicles as distributed artificial organelles for bacterial activation.

ABSTRACT: Intercellular communication is a hallmark of living systems. As such, engineering artificial cells that possess this behavior has been at the heart of activities in bottom-up synthetic biology. Communication between artificial and living cells has potential to confer novel capabilities to living organisms that could be exploited in biomedicine and biotechnology. However, most current approaches rely on the exchange of chemical signals that cannot be externally controlled. Here, we report two types of remote-controlled vesicle-based artificial organelles that translate physical inputs into chemical messages that lead to bacterial activation. Upon light or temperature stimulation, artificial cell membranes are activated, releasing signaling molecules that induce protein expression in Esch

SUBMITTER: Gispert I 

PROVIDER: S-EPMC9586261 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature