The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility.
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ABSTRACT:
SUBMITTER: Comas-Armangue G
PROVIDER: S-EPMC9599218 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
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The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility.
Comas-Armangue Gemma G Makharadze Lela L Gomez-Velazquez Melisa M Teperino Raffaele R
Biomedicines 20221001 10
While a dramatic increase in obesity and related comorbidities is being witnessed, the underlying mechanisms of their spread remain unresolved. Epigenetic and other non-genetic mechanisms tend to be prominent candidates involved in the establishment and transmission of obesity and associated metabolic disorders to offspring. Here, we review recent findings addressing those candidates, in the context of maternal and paternal influences, and discuss the effectiveness of preventive measures. ...[more]
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