Repurposed Effect of ¹⁷⁷Lu-DOTATATE in the Treatment of Mantle Cell Lymphoma.

ABSTRACT: Mantle cell lymphoma (MCL) is an uncommon subcategory of non-Hodgkin lymphoma (NHL). Pathogenesis primarily includes overexpression of CCND1 and SOX11 along with other molecular aberrations. Lutetium ¹⁷⁷Lu-DOTATATE is a radiolabeled somatostatin analogue used for the treatment of gastrointestinal neuroendocrine tumors. There are no clinical data supporting the use of Lutetium ¹⁷⁷Lu-DOTATATE in the treatment of lymphoma. We describe the case of an 84-year-old man with a history of MCL and carcinoid tumor of the lung. Following progression of the carcinoid malignancy, the patient was treated with Lutetium ¹⁷⁷Lu-DOTATATE. After treatment, there was an overall improvement of the patient's MCL that was demonstrated by stable lymphadenopathy on seri

SUBMITTER: Elajami MK 

PROVIDER: S-EPMC9599960 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature