Older Patients with Acute Myeloid Leukemia Deserve Individualized Treatment.

ABSTRACT:

Purpose of review

Treatment of elderly patients with acute myeloid leukemia is a known challenge for hematologists due to patient diversity, heterogeneous disease biology, and a rapidly evolving treatment landscape. Here, we highlight the importance of determining fitness, review the latest therapeutic developments, and discuss clinical scenarios to provide guidance on individualized treatment for older AML patients.

Recent findings

Several factors, like age, performance status, and comorbidities, play a role in fitness and are associated with outcome. Comorbidity scoring systems and geriatric assessments are tools to help physicians select the most appropriate treatment for each patient. The addition of venetoclax, targeted therapy with IDH1/2 and FLT3 inhibitors, and enhan

SUBMITTER: de Leeuw DC 

PROVIDER: S-EPMC9606099 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature