Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial.

ABSTRACT:

Importance

Whether selective decontamination of the digestive tract (SDD) reduces mortality in critically ill patients remains uncertain.

Objective

To determine whether SDD reduces in-hospital mortality in critically ill adults.

Design, setting, and participants

A cluster, crossover, randomized clinical trial that recruited 5982 mechanically ventilated adults from 19 intensive care units (ICUs) in Australia between April 2018 and May 2021 (final follow-up, August 2021). A contemporaneous ecological assessment recruited 8599 patients from participating ICUs between May 2017 and August 2021.

Interventions

ICUs were randomly assigned to adopt or not adopt a SDD strategy for 2 alternating 12-month periods, separated by a 3-month interperiod gap. Patients in the SDD

SUBMITTER: SuDDICU Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group 

PROVIDER: S-EPMC9607966 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature