Performance evaluation of a preclinical SPECT/CT system for multi-animal and multi-isotope quantitative experiments.

ABSTRACT: The aim was to study the performance of the U-SPECT⁶/CT E-class system for preclinical imaging, to later demonstrate the viability of simultaneous multi-animal and multi-isotope imaging with reliable quantitative accuracy. The performance of the SPECT was evaluated for two collimators dedicated for mouse (UHS-M) and rat imaging (UHR-RM) in terms of sensitivity, energy resolution, uniformity and spatial resolution. Point sources, hot‑rod and uniform phantoms were scanned, and additional tests were carried out to evaluate singular settings such as simultaneous multi-isotope acquisition and imaging with a multi-bed system. For in-vivo evaluation, simultaneous triple-isotope and multi-animal studies were performed on mice. Sensitivity for ^99mTc was 2370 cps/MBq for the UH

SUBMITTER: Prieto E 

PROVIDER: S-EPMC9616809 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature