Placebo administration for dry eye disease: a level I evidence based systematic review and meta-analysis.

ABSTRACT:

Background

The efficacy of various common treatment options for dry eye disease (DED) has been investigated against placebo. However, the potential beneficial effect of placebo in the management of DED is still unclear.

Aim

This meta-analysis investigated the impact of placebo administration in DED in Ocular Surface Disease Index (OSDI), Schirmer I test (SIT), tear breakup time (TBUT), corneal staining, and complications.

Method

This meta-analysis and systematic review was conducted according to the 2020 PRISMA guidelines. In March 2022, Pubmed, Web of Science, Google Scholar, and Embase were accessed. All the randomised clinical trials which investigated any active treatment against a placebo control group were considered. The following data were extracted at baselin

SUBMITTER: Prinz J 

PROVIDER: S-EPMC9618542 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature