Comorbidity between lung cancer and COVID-19 pneumonia: role of immunoregulatory gene transcripts in high ACE2-expressing normal lung.

ABSTRACT:

Background

SARS-CoV-2 (COVID-19) elicits a T-cell antigen-mediated immune response of variable efficacy. To understand this variability, we explored transcriptomic expression of angiotensin-converting enzyme 2 (ACE2, the SARS-CoV-2 receptor) and of immunoregulatory genes in normal lung tissues from patients with non-small cell lung cancer (NSCLC).

Methods

This study used the transcriptomic and the clinical data for NSCLC patients generated during the CHEMORES study [n = 123 primary resected (early-stage) NSCLC] and the WINTHER clinical trial (n = 32 metastatic NSCLC).

Results

We identified patient subgroups with high and low ACE2 expression (p = 1.55 × 10^-19) in normal lung tissue, presumed to be at higher and lower risk,

SUBMITTER: Lazar V 

PROVIDER: S-EPMC9618916 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature