Imbalance between the function of Na⁺-K⁺-2Cl and K⁺-Cl impairs Cl^- homeostasis in human focal cortical dysplasia.

ABSTRACT:

Objective

Altered expression patterns of Na⁺-K⁺-2Cl^- (NKCC1) and K⁺-Cl^- (KCC2) co-transporters have been implicated in the pathogenesis of epilepsy. Here, we assessed the effects of imbalanced NKCC1 and KCC2 on γ-aminobutyric acidergic (GABAergic) neurotransmission in certain brain regions involved in human focal cortical dysplasia (FCD).

Materials and methods

We sought to map a micro-macro neuronal network to better understand the epileptogenesis mechanism. In patients with FCD, we resected cortical tissue from the seizure the onset zone (SOZ) and the non-seizure onset zone (non-SOZ) inside the epileptogenic zone (EZ). Additionally, we resected non-epileptic neocortical tissue from the patients with mesial temporal lobe

SUBMITTER: Liu R 

PROVIDER: S-EPMC9621392 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature