Oncological outcomes of neoadjuvant chemotherapy in patients with resectable synchronous colorectal liver metastasis: A result from a propensity score matching study.

ABSTRACT:

Background

The efficacy and safety of neoadjuvant chemotherapy (NAC) in treating resectable synchronous colorectal liver metastases (CRLM) remain controversial.

Methods

Data from CRLM patients who underwent simultaneous liver resection between January 2015 and December 2019 were collected from the Surveillance, Epidemiology, and End Results (SEER) database (SEER cohort, n=305) and a single Chinese Cancer Center (NCC cohort, n=268). Using a 1:2 ratio of propensity score matching (PSM), the prognostic impact of NAC for patients who underwent NAC before surgical treatment and patients who underwent surgical treatment alone was evaluated.

Results

After PSM, there was no significant difference in overall survival (OS) between patients receiving NAC prior to CRLM resection

SUBMITTER: Jiang YJ 

PROVIDER: S-EPMC9623041 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature