IL-1β is not critical to chronic heart dysfunction in mice with Chagas disease.

ABSTRACT: Long after Trypanosoma cruzi infection, 40% of individuals develop a progressive chronic chagasic cardiomyopathy (CCC), with systolic dysfunction and arrhythmias. Since we previously showed IL-1β mediates the development of systolic dysfunction and cardiac arrhythmias in diabetes mellitus and cardiorenal syndrome, and IL-1β remains elevated in Chagas disease patients, here we tested the role of IL-1β in CCC using a mouse model. Mice deficient in IL-1R expression (Il-1r^-/- ) survived acute T. cruzi infection with greater parasitemia than controls but did not lose weight as wild-type (WT) did. At the chronic stage, WT presented prolonged ventricular repolarization intervals (QJ), while Il-1r^-/- presented intervals like noninfected controls. I

SUBMITTER: Sousa Oliveira CV 

PROVIDER: S-EPMC9627615 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature