Impact of different oral treatments on the composition of the supragingival plaque microbiome.

ABSTRACT:

Background

Dental plaque consists of a diverse microbial community embedded in a complex structure of exopolysaccharides. Dental biofilms form a natural barrier against pathogens but lead to oral diseases in a dysbiotic state.

Objective

Using a metaproteome approach combined with a standard plaque-regrowth study, this pilot study examined the impact of different concentrations of lactoperoxidase (LPO) on early plaque formation, and active biological processes.

Design

Sixteen orally healthy subjects received four local treatments as a randomized single-blind study based on a cross-over design. Two lozenges containing components of the LPO-system in different concentrations were compared to a placebo and Listerine®. The newly formed dental plaque was analyzed by mass sp

SUBMITTER: Rabe A 

PROVIDER: S-EPMC9629129 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature