Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study.

ABSTRACT:

Background

The positive association of choline for cognition has been reported in both animal and human studies, yet the associations of choline with the risks of incident dementia or Alzheimer's disease (AD) in humans is unclear.

Objectives

Our objective was to test the hypothesis that lower or higher dietary choline intake is associated with increased or decreased, respectively, risks of incident dementia and AD.

Methods

Data from the Framingham Heart Study Offspring Cohort exam 5 to exam 9 were used. Participants were free of dementia and stroke, with a valid self-reported 126-item Harvard FFQ at exam 5. The intakes of total choline, its contributing compounds, and betaine were estimated based on a published nutrient database. The intakes were updated at each exam

SUBMITTER: Yuan J 

PROVIDER: S-EPMC9630864 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature