Development of AB₃-Type Novel Phthalocyanine and Porphyrin Photosensitizers Conjugated with Triphenylphosphonium for Higher Photodynamic Efficacy.

ABSTRACT: There are a number of lipophilic cations that can be chosen; the triphenylphosphonium (TPP) ion is particularly unique for mitochondrion targeting, mainly due to its simplicity in structure and ease to be linked to the target molecules. In this work, mitochondrion-targeted AB₃-type novel phthalocyanine and porphyrin photosensitizers (PSs) were synthesized and their photophysical photochemical properties were defined. Fluorescence quantum yields (Φ_F) are 0.009, 0.14, 0.13, and 0.13, and the singlet-oxygen quantum yields (Φ_Δ) are 0.27, 0.75, 0.57, and 0.58 for LuPcPox(OAc), AB ₃ TPP-Pc, AB ₃ TPP-Por-C4, and AB ₃ TPP-Por-C6, respectively. To evaluate the phot

SUBMITTER: Onal E 

PROVIDER: S-EPMC9631755 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature