Exploration of shared features of B cell receptor and T cell receptor repertoires reveals distinct clonotype clusters.

ABSTRACT: Although B cells and T cells are integral players of the adaptive immune system and act in co-dependent ways to orchestrate immune responses, existing methods to study the immune repertoire have largely focused on separate analyses of B cell receptor (BCR) and T cell receptor (TCR) repertoires. Based on our hypothesis that the shared history of immune exposures and the shared cellular machinery for recombination result in similarities between BCR and TCR repertoires in an individual, we examine any commonalities and interrelationships between BCR and TCR repertoires. We find that the BCR and TCR repertoires have covarying clonal architecture and diversity, and that the pattern of correlations appears to be altered in immune-mediated diseases. Furthermore, hierarchical clustering of public

SUBMITTER: Hong SB 

PROVIDER: S-EPMC9632170 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature