An SNN retrocopy insertion upstream of GPR22 is associated with dark red coat color in Poodles.

ABSTRACT: Pigment production and distribution is controlled through multiple genes, resulting in a wide range of coat color phenotypes in dogs. Dogs that produce only the pheomelanin pigment vary in intensity from white to deep red. The Poodle breed has a wide range of officially recognized coat colors, including the pheomelanin-based white, cream, apricot, and red coat colors, which are not fully explained by the previously identified genetic variants involved in pigment intensity. Here, a genome-wide association study for pheomelanin intensity was performed in Poodles which identified an association on canine chromosome 18. Whole-genome sequencing data revealed an SNN retrocopy insertion (SNNL1) in apricot and red Poodles within the associated region on chromosome 18. While equal numbers of melano

SUBMITTER: Batcher K 

PROVIDER: S-EPMC9635648 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature