Vitamin D supplementation for the prevention of total cancer incidence and mortality: An updated systematic review and meta-analysis.

ABSTRACT:

Introduction

Previous randomized controlled trials (RCTs) and meta-analyses of RCTs evaluating vitamin D supplementation for the prevention of cancer incidence and mortality have found inconsistent results and no meta-analysis has assessed the quality of the evidence available. We, therefore, aimed to perform an updated meta-analysis by including recent large-scale RCTs and assessing the quality of the pooled evidence.

Methods

We searched several databases and trial registers from inception to April 2022. We used a random-effects model to estimate pooled risk ratios (RRs) and 95% confidence intervals (CIs). We used the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) considerations to evaluate the certainty of evidence.

Results

We included 13

SUBMITTER: Cheema HA 

PROVIDER: S-EPMC9636470 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature