Shared Inherited Genetics of Benign Prostatic Hyperplasia and Prostate Cancer.

ABSTRACT:

Background

The association between benign prostatic hyperplasia (BPH) and prostate cancer (PCa) remains controversial, largely due to a detection bias in traditional observational studies.

Objective

To assess the association between BPH and PCa using inherited single nucleotide polymorphisms (SNPs).

Design setting and participants

The participants were White men from the population-based UK Biobank (UKB).

Outcome measurements and statistical analysis

The association between BPH and PCa was tested for (1) phenotypic correlation using chi-square, (2) genetic correlation (r _g) based on genome-wide SNPs using linkage disequilibrium score regression, and (3) cross-disease genetic associations based on known risk-associated SNPs (15 for BPH and 239

SUBMITTER: Glaser A 

PROVIDER: S-EPMC9638770 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature