Periventricular rather than deep white matter hyperintensities mediate effects of hypertension on cognitive performance in the population-based 1000BRAINS study.

ABSTRACT:

Objectives

White matter hyperintensities (WMH) of presumed vascular origin are frequent in cerebral MRI of older people. They represent a sign of small vessel disease, are promoted by arterial hypertension, and relate to cognitive deficits. The interdependence of blood pressure and its treatment, WMH, and cognitive performance has not systematically been studied in population-based studies.

Methods

Consequently, we analysed the interdependence of SBP, DBP, and antihypertensive medications, as well as BP/treatment category, with WMH and cognitive performance in 560 participants of the population-based 1000BRAINS study.

Results

BP, its treatment, and BP/treatment category were moderately associated with cognitive performance (e.g. unadjusted β  = -0.10, 95%CI = -0.19 to

SUBMITTER: Gronewold J 

PROVIDER: S-EPMC9640292 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature