FMR1 promotes the progression of colorectal cancer cell by stabilizing EGFR mRNA in an m⁶A-dependent manner.

ABSTRACT: FMR1, a new m⁶A reader, is known to be involved in the regulation of cancer progression. However, its role, regulatory mechanism, and clinical significance in colorectal cancer (CRC) are elusive. Here, we showed that FMR1 was upregulated in CRC, and it promoted proliferation and metastasis of CRC cells in vitro and in vivo. Mechanically, FMR1 recognized the m⁶A-modification site in EGFR mRNA, a key molecule in cancer occurrence and targeted therapy, sustained its stability and maintained its expression in an m⁶A-dependent manner, thereby promoting the tumorigenesis and metastasis of CRC. And the effect of FMR1 knockdown in CRC cells could be abolished by METTL3. Furthermore, FMR1 shRNA plasmid carried by attenuated Salmonella has an effective anti-tumor eff

SUBMITTER: Hu Y 

PROVIDER: S-EPMC9643526 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature