Examination of host genetic effects on nasal microbiome composition.

ABSTRACT:

Background

Genetic predisposition increases risk for asthma, and distinct nasal microbial compositions are associated with asthma. Host genetics might shape nasal microbiome composition.

Objective

We examined associations between host genetics and nasal microbiome composition.

Methods

Nasal samples were collected from 584 participants from the Mount Sinai Health System, New York. Seventy-seven follow-up samples were collected from a subset of 40 participants. 16S rRNA sequencing and RNA sequencing were performed on nasal samples. Beta diversity was calculated, variant calling on RNA sequencing data was performed, and genetic relatedness between individuals was determined. Using linear regression models, we tested for associations between genetic relatedness and nasal

SUBMITTER: Irizar H 

PROVIDER: S-EPMC9643606 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature