Investigating Genetic Determinants of Plasma Inositol Status in Adult Humans.

ABSTRACT:

Background

Myo-inositol (MI) is incorporated into numerous biomolecules, including phosphoinositides and inositol phosphates. Disturbance of inositol availability or metabolism is associated with various disorders, including neurological conditions and cancers, whereas supplemental MI has therapeutic potential in conditions such as depression, polycystic ovary syndrome, and congenital anomalies. Inositol status can be influenced by diet, synthesis, transport, utilization, and catabolism.

Objectives

We aimed to investigate potential genetic regulation of circulating MI status and to evaluate correlation of MI concentration with other metabolites.

Methods

GC-MS was used to determine plasma MI concentration of >2000 healthy, young adults (aged 18-28 y) from the Trinity S

SUBMITTER: Weston E 

PROVIDER: S-EPMC9644178 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature