Updated trabecular bone score accounting for the soft tissue thickness (TBS_TT) demonstrated significantly improved bone microstructure with denosumab in the FREEDOM TBS post hoc analysis.

ABSTRACT: TBS algorithm has been updated to account for regional soft tissue noise. In postmenopausal women with osteoporosis, denosumab improved tissue thickness-adjusted TBS vs placebo independently of bone mineral density over 3 years, with the magnitude of changes from baseline or placebo numerically greater than body mass index-adjusted TBS.

Introduction

To evaluate the effect of denosumab on bone microarchitecture assessed by trabecular bone score (TBS) in the FREEDOM study using the updated algorithm that accounts for regional soft tissue thickness (TBS_TT) in dual-energy X-ray absorptiometry (DXA) images and to compare percent changes from baseline and placebo with classical body mass index (BMI)-adjusted TBS (TBS_BMI).

Methods

Postmenopausal women with lumb

SUBMITTER: Hans D 

PROVIDER: S-EPMC9652244 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature