Cytomegalovirus viremia as a risk factor for mortality in HIV-associated cryptococcal and tuberculous meningitis.

ABSTRACT:

Objectives

CMV viremia is associated with increased mortality in persons with HIV. We previously demonstrated that CMV viremia was a risk factor for 10-week mortality in antiretroviral therapy (ART)-naïve persons with cryptococcal meningitis. We investigated whether similar observations existed over a broader cohort of patients with HIV-associated meningitis at 18 weeks.

Methods

We prospectively enrolled Ugandans with cryptococcal or TB meningitis into clinical trials in 2015-2019. We quantified CMV DNA concentrations from stored baseline plasma or serum samples from 340 participants. We compared 18-week survival between those with and without CMV viremia.

Results

We included 308 persons with cryptococcal meningitis and 32 with TB meningitis, of whom 121 (36%) had det

SUBMITTER: Skipper CP 

PROVIDER: S-EPMC9653033 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature