Comprehensive Analysis Revealed the Potential Roles of N⁶-Methyladenosine (m⁶A) Mediating E. coli F18 Susceptibility in IPEC-J2 Cells.

ABSTRACT: Post-weaning diarrhea caused by enterotoxigenic Escherichia coli F18 (E. coli F18) causes significant economic losses for pig producers. N⁶-methyladenosine (m⁶A) is a highly abundant epitranscriptomic marker that has been found to be involved in regulating the resistance of host cells to pathogenic infection, but its potential role in E. coli F18-exposed intestinal porcine epithelial cells (IPEC-J2) remains undetermined. Here, we demonstrated that m⁶A and its regulators modulate E. coli F18 susceptibility. Briefly, we revealed that the Wilms' tumor 1-associating protein (WTAP) expressions were markedly elevated in IPEC-J2 cells upon E. coli F18 exposure. WTAP are required for the regulation of E. coli

SUBMITTER: Wu Z 

PROVIDER: S-EPMC9654476 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature