Association between Ancestry-Specific 6q25 Variants and Breast Cancer Subtypes in Peruvian Women.

ABSTRACT:

Background

Breast cancer incidence in the United States is lower in Hispanic/Latina (H/L) compared with African American/Black or Non-Hispanic White women. An Indigenous American breast cancer-protective germline variant (rs140068132) has been reported near the estrogen receptor 1 gene. This study tests the association of rs140068132 and other polymorphisms in the 6q25 region with subtype-specific breast cancer risk in H/Ls of high Indigenous American ancestry.

Methods

Genotypes were obtained for 5,094 Peruvian women with (1,755) and without (3,337) breast cancer. Associations between genotype and overall and subtype-specific risk for the protective variant were tested using logistic regression models and conditional analyses, including other risk-associated polymorphisms in

SUBMITTER: Zavala VA 

PROVIDER: S-EPMC9662925 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature