Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins.

ABSTRACT:

Objective

Fetal growth restriction (FGR) is a devastating pregnancy complication that increases the risk of perinatal mortality and morbidity. This study aims to determine the combined and relative effects of genetic and intrauterine environments on neonatal microbial communities and to explore selective FGR-induced gut microbiota disruption, metabolic profile disturbances and possible outcomes.

Design

We profiled and compared the gut microbial colonisation of 150 pairs of twin neonates who were classified into four groups based on their chorionicity and discordance of fetal birth weight. Gut microbiota dysbiosis and faecal metabolic alterations were determined by 16S ribosomal RNA and metagenomic sequencing and metabolomics, and the long-term effects were explored by survey

SUBMITTER: Yang J 

PROVIDER: S-EPMC9664093 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature