Dataset Information

Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins.

ABSTRACT:

Objective

Fetal growth restriction (FGR) is a devastating pregnancy complication that increases the risk of perinatal mortality and morbidity. This study aims to determine the combined and relative effects of genetic and intrauterine environments on neonatal microbial communities and to explore selective FGR-induced gut microbiota disruption, metabolic profile disturbances and possible outcomes.

Design

We profiled and compared the gut microbial colonisation of 150 pairs of twin neonates who were classified into four groups based on their chorionicity and discordance of fetal birth weight. Gut microbiota dysbiosis and faecal metabolic alterations were determined by 16S ribosomal RNA and metagenomic sequencing and metabolomics, and the long-term effects were explored by surveys of physical and neurocognitive development conducted after 2~3 years of follow-up.

Results

Adverse intrauterine environmental factors related to selective FGR dominate genetics in their effects of elevating bacterial diversity and altering the composition of early-life gut microbiota, and this effect is positively related to the severity of selective FGR in twins. The influence of genetic factors on gut microbes diminishes in the context of selective FGR. Gut microbiota dysbiosis in twin neonates with selective FGR and faecal metabolic alterations features decreased abundances of Enterococcus and Acinetobacter and downregulated methionine and cysteine levels. Correlation analysis indicates that the faecal cysteine level in early life is positively correlated with the physical and neurocognitive development of infants.

Conclusion

Dysbiotic microbiota profiles and pronounced metabolic alterations are associated with selective FGR affected by adverse intrauterine environments, emphasising the possible effects of dysbiosis on long-term neurobehavioural development.

SUBMITTER: Yang J

PROVIDER: S-EPMC9664093 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins.

Yang Jing J Hou Lingling L Wang Jinfeng J Xiao Liwen L Zhang Jinyang J Yin Nanlin N Yao Su S Cheng Kun K Zhang Wen W Shi Zhonghua Z Wang Jing J Jiang Hai H Huang Nana N You Yanxia Y Lin Mingmei M Shang Ruiyan R Wei Yuan Y Zhao Yangyu Y Zhao Fangqing F

Gut 20220406 12

<h4>Objective</h4>Fetal growth restriction (FGR) is a devastating pregnancy complication that increases the risk of perinatal mortality and morbidity. This study aims to determine the combined and relative effects of genetic and intrauterine environments on neonatal microbial communities and to explore selective FGR-induced gut microbiota disruption, metabolic profile disturbances and possible outcomes.<h4>Design</h4>We profiled and compared the gut microbial colonisation of 150 pairs of twin ne ...[more]

PMID: 35387876

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Dataset Information

Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins.

Objective

Design

Results

Conclusion

Publications

Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins.

Similar Datasets

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