Ancestry, ACKR1 and leucopenia in patients with systemic lupus erythematosus.

ABSTRACT:

Objective

SLE is more prevalent in populations of African (AA) than European ancestry (EA) and leucopenia is common. A homozygous variant in ACKR1 (rs2814778-CC) is associated with lower white cell counts; the variant is common in AA but not EA populations. We hypothesised that in SLE: (1) leucopenia is more frequent in patients of AA than EA, and (2) the ACKR1-CC genotype accounts for the higher frequency of leucopenia in AA patients.

Methods

We performed a retrospective cohort study in patients with SLE at a tertiary care system. Ancestry was defined by genetic principal components. We compared the rate of leucopenia, thrombocytopenia and anaemia between (a) EA and AA patients, and (b) ACKR1-CT/TT and CC genotype in AA patients.

Results

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SUBMITTER: Chung CP 

PROVIDER: S-EPMC9664301 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature