A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients.
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ABSTRACT:
SUBMITTER: Tardiveau C
PROVIDER: S-EPMC9665875 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
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A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients.
Tardiveau Claire C Monneret Guillaume G Lukaszewicz Anne-Claire AC Cheynet Valérie V Cerrato Elisabeth E Imhoff Katia K Peronnet Estelle E Bodinier Maxime M Kreitmann Louis L Blein Sophie S Llitjos Jean-François JF Conti Filippo F Gossez Morgane M Buisson Marielle M Yonis Hodane H Cour Martin M Argaud Laurent L Delignette Marie-Charlotte MC Wallet Florent F Dailler Frederic F Monard Céline C Brengel-Pesce Karen K Venet Fabienne F
Frontiers in immunology 20221101
Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed that a multiplex transcriptomic panel prototype termed Immune Profiling Panel (IPP) could capture the dysregulation of immune responses of ICU COVID-19 patients at admission. Nine transcripts were associated with mortality in univariate analysis and this 9-mRNA ...[more]
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