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Production of a recyclable nanobiocatalyst to synthesize quinazolinone derivatives.

ABSTRACT: Nanobiocatalysts (NBCs) are an emerging innovation that paves the way toward sustainable and eco-friendly endeavors. In the quest for a robust and reusable nanobiocatalyst, herein, we report a nanobiocatalyst, namely CALB@MrGO, developed via immobilizing Candida antarctica lipase B onto the surface of Fe₃O₄-decorated reduced graphene oxide (MrGO). Next, the enormous potential of the NBC (CALB@MrGO) was checked by employing it to synthesize clinically important quinazolinone derivatives in good to excellent yield (70-95%) using differently substituted aryl aldehydes with 2-aminobenzamide. Further, the synthetic utility and generality of this protocol was proved by setting up a gram-scale reaction, which afforded the product in 87% yield. The green chemistry metrics calculated for the gram-scale reaction those prove the greenness of this protocol.

SUBMITTER: Budhiraja M

PROVIDER: S-EPMC9667765 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Production of a recyclable nanobiocatalyst to synthesize quinazolinone derivatives.

Budhiraja Meenakshi M Chudasama Bhupendra B Ali Amjad A Ali Amjad A Tyagi Vikas V

RSC advances 20221116 49

Nanobiocatalysts (NBCs) are an emerging innovation that paves the way toward sustainable and eco-friendly endeavors. In the quest for a robust and reusable nanobiocatalyst, herein, we report a nanobiocatalyst, namely CALB@MrGO, developed via immobilizing Candida antarctica lipase B onto the surface of Fe3O4-decorated reduced graphene oxide (MrGO). Next, the enormous potential of the NBC (CALB@MrGO) was checked by employing it to synthesize clinically important ...[more]

PMID: 36425315

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