A manganese(i)tricarbonyl-catalyst for near room temperature alkene and alkyne hydroarylation.
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ABSTRACT: Developing more efficient catalytic processes using abundant and low toxicity transition metals is key to enable their mainstream use in synthetic chemistry. We have rationally designed a new Mn(i)-catalyst for hydroarylation reactions that displays much improved catalytic activity over the commonly used MnBr(CO)5. Our catalyst, MnBr(CO)3(MeCN)2, avoids the formation of the off-cycle manganacycle-(CO)4 species responsible for low catalyst activity, allowing near room temperature hydroarylation of alkenes and alkynes with broad functional group tolerance including late stage functionalisation and diversification of bioactive molecules.
SUBMITTER: Choudhary S
PROVIDER: S-EPMC9667916 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
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