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A manganese(i)tricarbonyl-catalyst for near room temperature alkene and alkyne hydroarylation.

ABSTRACT: Developing more efficient catalytic processes using abundant and low toxicity transition metals is key to enable their mainstream use in synthetic chemistry. We have rationally designed a new Mn(i)-catalyst for hydroarylation reactions that displays much improved catalytic activity over the commonly used MnBr(CO)₅. Our catalyst, MnBr(CO)₃(MeCN)₂, avoids the formation of the off-cycle manganacycle-(CO)₄ species responsible for low catalyst activity, allowing near room temperature hydroarylation of alkenes and alkynes with broad functional group tolerance including late stage functionalisation and diversification of bioactive molecules.

SUBMITTER: Choudhary S

PROVIDER: S-EPMC9667916 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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A manganese(i)tricarbonyl-catalyst for near room temperature alkene and alkyne hydroarylation.

Choudhary Shweta S Cannas Diego M DM Wheatley Matthew M Larrosa Igor I

Chemical science 20221026 44

Developing more efficient catalytic processes using abundant and low toxicity transition metals is key to enable their mainstream use in synthetic chemistry. We have rationally designed a new Mn(i)-catalyst for hydroarylation reactions that displays much improved catalytic activity over the commonly used MnBr(CO)5. Our catalyst, MnBr(CO)3(MeCN)2, avoids the formation of the off-cycle manganacycle-(CO)4 species responsible for low catalyst activity, all ...[more]

PMID: 36425483

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