Impact of chitosan administration on titanium dioxide nanoparticles induced testicular dysfunction.

ABSTRACT: The potential reproductive toxic effects of oral TiO₂ NPs in adult male rats as well as the possible alleviation of chitosan administration was investigated. Animals were allocated to four groups; the first group received deionized water and was assigned as a control group. In the second group, rats received chitosan at a dose of 5 mg/kg BW/day. The third group was designed for administration of TiO₂ NPs at a dose of 150 mg/kg BW/day (1/80 LD₅₀). Rats in the fourth group received both TiO₂ NPs and chitosan. After 14 days, TiO₂ NPs induced testicular lipid peroxidation as well as oxidative stress. Nano-titanium significantly upregulated genes that encode apoptosis and inflammation in testicular tissue. Moreover, it induced histological

SUBMITTER: Halawa AA 

PROVIDER: S-EPMC9669025 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature