Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction.

ABSTRACT: Animals both explore and avoid novel objects in the environment, but the neural mechanisms that underlie these behaviors and their dynamics remain uncharacterized. Here, we used multi-point tracking (DeepLabCut) and behavioral segmentation (MoSeq) to characterize the behavior of mice freely interacting with a novel object. Novelty elicits a characteristic sequence of behavior, starting with investigatory approach and culminating in object engagement or avoidance. Dopamine in the tail of the striatum (TS) suppresses engagement, and dopamine responses were predictive of individual variability in behavior. Behavioral dynamics and individual variability are explained by a reinforcement-learning (RL) model of threat prediction in which behavior arises from a novelty-induced initial threat predi

SUBMITTER: Akiti K 

PROVIDER: S-EPMC9671833 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature