STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression.

ABSTRACT:

Background & aims

Signal transducer and activator of transcription 3 (STAT3) is known as a pro-oncogenic transcription factor. Regarding liver carcinogenesis, however, it remains controversial whether activated STAT3 is pro- or anti-tumorigenic. This study aimed to clarify the significance and mechanism of STAT3 activation in hepatocellular carcinoma (HCC).

Methods

Hepatocyte-specific Kras-mutant mice (Alb-Cre Kras^LSL-G12D/+; Kras^G12D mice) were used as a liver cancer model. Cell lines of hepatoma and stromal cells including stellate cells, macrophages, T cells, and endothelial cells were used for culture. Surgically resected 12 HCCs were used for human analysis.

Results

Tumors in Kras^G12D mice showed up-regulation of phosphorylated ST

SUBMITTER: Makino Y 

PROVIDER: S-EPMC9672888 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature