Relationships of circulating CD4⁺ T cell subsets and cytokines with the risk of relapse in patients with Crohn's disease.

ABSTRACT:

Background and aims

We aimed to analyze circulating CD4⁺ T cell subsets and cytokines during the course of Crohn's disease (CD).

Methods and results

CD4⁺ T cell subsets, ultrasensitive C-reactive protein (usCRP), and various serum cytokines (IL-6, IL-8, IL-10, IL-13, IL-17A, IL-23, TNFα, IFNγ, and TGFβ) were prospectively monitored every 3 months for 1 year, using multicolor flow cytometry and an ultrasensitive Erenna method in CD patients in remission at inclusion. Relapse occurred in 35 out of the 113 consecutive patients (31%). For patients in remission within 4 months prior to relapse and at the time of relapse, there was no significant difference in Th1, Th17, Treg, and double-positive CD4⁺ T cell subsets co-expressing either IFNγ and FO

SUBMITTER: Duclaux-Loras R 

PROVIDER: S-EPMC9674020 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature