Clinical implications of CD4⁺ T cell subsets in adult atopic asthma patients.

ABSTRACT:

Background

T cells play a central role in chronic inflammation in asthma. However, the roles of individual subsets of T cells in the pathology of asthma in patients remain to be better understood.

Methods

We investigated the potential signatures of T cell subset phenotypes in asthma using fresh whole blood from adult atopic asthma patients (n = 43) and non-asthmatic control subjects (n = 22). We further assessed their potential clinical implications by correlating asthma severity.

Results

We report four major features of CD4⁺ T cells in the blood of atopic asthma patients. First, patients had a profound increase of CCR7⁺ memory CD4⁺ T cells, but not CCR7^- memory CD4⁺ T cells. Second, an increase in CCR4⁺

SUBMITTER: Wiest M 

PROVIDER: S-EPMC5833086 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature