A Note on the Conditioning of the H^-1 Matrix Used in Single-Step GBLUP.

ABSTRACT: The single-step genomic BLUP (ssGBLUP) is used worldwide for the simultaneous genetic evaluation of genotyped and non-genotyped animals. It is easily extendible to all BLUP models by replacing the pedigree-based additive genetic relationship matrix (A) with an augmented pedigree-genomic relationship matrix (H). Theoretically, H does not introduce any artificially inflated variance. However, inflated genetic variances have been observed due to the incomparability between the genomic relationship matrix (G) and A used in H. Usually, G is blended and tuned with A22 (the block of A for genotyped animals) to improve its numerical condition and compatibility. If deflation/inflation is still needed, a common approach is weighting G-1-A22-1 i

SUBMITTER: Nilforooshan MA 

PROVIDER: S-EPMC9686757 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature