Biocompatibility and Connectivity of Semiconductor Nanostructures for Cardiac Tissue Engineering Applications.

ABSTRACT: Nano- or microdevices, enabling simultaneous, long-term, multisite, cellular recording and stimulation from many excitable cells, are expected to make a strategic turn in basic and applied cardiology (particularly tissue engineering) and neuroscience. We propose an innovative approach aiming to elicit bioelectrical information from the cell membrane using an integrated circuit (IC) bearing a coating of nanowires on the chip surface. Nanowires grow directly on the backend of the ICs, thus allowing on-site amplification of bioelectric signals with uniform and controlled morphology and growth of the NWs on templates. To implement this technology, we evaluated the biocompatibility of silicon and zinc oxide nanowires (NWs), used as a seeding substrate for cells in culture, on two different prim

SUBMITTER: Gaetani R 

PROVIDER: S-EPMC9687646 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature