A subtractive proteomics approach for the identification of immunodominant Acinetobacter baumannii vaccine candidate proteins.

ABSTRACT:

Background

Acinetobacter baumannii is one of the most life-threatening multidrug-resistant pathogens worldwide. Currently, 50%-70% of clinical isolates of A. baumannii are extensively drug-resistant, and available antibiotic options against A. baumannii infections are limited. There is still a need to discover specific de facto bacterial antigenic proteins that could be effective vaccine candidates in human infection. With the growth of research in recent years, several candidate molecules have been identified for vaccine development. So far, no public health authorities have approved vaccines against A. baumannii.

Methods

This study aimed to identify immunodominant vaccine candidate proteins that can be immunoprecipitated specifically with

SUBMITTER: Acar MB 

PROVIDER: S-EPMC9687788 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature